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of energy balance remains controversial, but the scienti c impact of this powerful demonstration of molecular genetics can hardly be underestimated (Kandel, Schwartz and Jessell, 2000). Leptin is a 14-kDa protein, structurally related to the cytokines, and is highly conserved among mammals. It is expressed at high levels in adipose tissue, especially white adipose tissue; lower levels are found in stomach and placenta. Leptin ful ls many theoretical predictions for an adiposity signal. It is secreted by adipose tissue into the bloodstream, where its concentrations are proportional to fat mass (Ahima and Flier, 2000). Leptin is rapidly transported across the blood-brain barrier in the mediobasal hypothalamus and other regions, and so has ready access to the CNS regions that regulate energy homeostasis. It binds to receptors in several brain regions, notably the ARC and other hypothalamic areas (Malik and Young, 1996). When injected centrally in normal rodents, leptin inhibits eating and stimulates energy expenditure (via increased sympathetic stimulation), leading with repeated administration to loss of body weight and fat hence its name, from leptos , the Greek for thin . The loss of

(5.55) (5.56)

1999, p. 88) sees transaction costs as an important factor in the explanation of the choice of a coordination structure between organizations (hierarchical organization, market, or something in-between).

Now onto cosmetics. Do you like how the PC case looks Some cases will be very plain and utilitarian, whereas others can be quite dramatic looking, with neon lights, LED decoration, clear and panel windows to see the inside of the PC. Still others are molded into fancy sculptures. Although how your final PC will look might seem like a small consideration compared to, say, power or performance, it s still an important and sometimes overlooked consideration. Think carefully about the PC and where it will go. A case that s packed with glowing neon tubes and blinking LEDs can look great in the store, but will it look great when you get it home If the PC is going to be in a shared work space, will the others that inhabit that work space enjoy the neon/LED light show Will that alien head molding on the front of the PC fit in with the surroundings Does it matter Give this some thought, and work this into your thinking when buying a case. All this might seem like very minor considerations but they are important and can make the difference between a final PC that you re proud of and one you re not. If you are uncertain about a nonstandard PC case design, then err on the side of restraint and get a standard case you can always change the case later anyway.

C(z) = 0.5

6. From the content area of the DesignCenter, drag each of the blocks to the new tool palette. An icon appears on the tool palette for each block. 7. In the Folder List of the DesignCenter, navigate to acad.pat or aclt.pat, which contains hatch patterns. Click acad.pat or aclt.pat to display the hatch patterns in the content area.

3. the set of shape functions. In practice the differential operator is given, and the mesh can be optimized outside of the finite element solver. Therefore let us look at the last aspect in more detail.

Software-based RAID volumes are created using special logical volume management (LVM) software installed on the host operating system. The problem with software RAID is the additional load that it places on the host CPUs and memory. However, it provides the flexibility of using any disk that the OS can detect. The hot spares can be located on different subsystems to protect data from entire subsystem failure. There are five RAID levels, numbered from 1 to 5. (The number does not reflect a ranking in performance or availability.) There is also RAID-0. The zero means that there is no redundancy. Some of the RAID levels are combined to make new levels (such as RAID 0+1 and RAID 1+0). There are also other levels developed and marketed by some vendors. These unofficial levels are often only slight variations of the standard RAID levels.

Figure 27.9 (Continued )

Clarify mission, vision, values, and strategic destination statement Inform and motivate the executive leadership team Build the case for change Guide the executive leadership team to build a Strategy Map Guide the implementation teams to build a Tactical Action Plans Guide the implementation teams and metrics teams to define critical metrics Plan the communication and rollup Develop a fully functional Excel-based Balanced Scorecard that uses manual updates or database integration